Originally presented by Dr Angie Zhang
Melatonin is an endogenous hormone from pineal gland affecting circadian rhythm
Indications
- Insomnia, jet lag, shift work
- REM sleep disorders
- Dementia (sundowning)
- Few adverse effects
BDZ drawbacks
- Sedation
- Psychomotor impairment
- Amnesia
Cochrane 2020
- Systematic review + meta-analysis
- 27 RCTs = 2319 adult patients undergoing GA/regional anaesthesia
- Night before / on DOS:
- Melatonin
- Benzodiazepine
- Placebo
Results
- Melatonin out performed placebo
- Melatonin reduces pre-operative anxiety
- Melatonin was equivalent to BDZs
- With no difference in pre-operative anxiety
Links